Acceptable Strategies for Dealing With Hereditary Breast/Ovarian Cancer Risk

The Weakest Link: Risk Management Strategies for Dealing with Interdependencies

Networks increase interdependencies and this creates challenges for managing risks. This is especially apparent in areas such as security and enterprise risk management, where the actions of a single player in an interconnected network can wreak havoc on everyone in the network. The network, in this case, is only as strong as its weakest link. There are related problems in encouraging investmen...

Hereditary diffuse gastric cancer: strategies to reduce tumoral risk.

The main goal at a High-Risk Gastrointestinal Cancer Clinic is to identify individuals at increased risk of developing tumors for diagnosis them in presymptomatic stages, when they are potentially curable. We report an asymptomatic patient belonging to a family with hereditary diffuse gastric cancer syndrome with a novel pathogenic mutation in the E-cadherin gene. In the absence of any proven d...

Viable strategies for dealing with the uninsured.

Multigene Panel Testing for Hereditary Cancer Risk

Historically, an understanding of a patient and/or their family’s cancer risk and predisposition was based in large part on patient pedigree or family history, histology, and age at diagnosis. However, since the completion of the Human Genome Project, advances in technology have moved from pedigree to single-gene testing to multigene testing and next-generation sequencing. Advanced practitioner...

Breast MRI for women with hereditary cancer risk.

APPROXIMATELY A DECADE AGO, GERMLINE MUTAtions in BRCA1 and BRCA2 were identified as the most common detectable causes of a hereditary predisposition to breast (and ovarian) cancer. A recent meta-analysis of 22 studies indicated that the average risk of breast cancer by 70 years is 65% for women with BRCA1 mutations and 45% for BRCA2 mutations, although the risk may be substantially higher in s...